HDAC3-driven immunometabolic reprogramming in type 2 diabetes and its complications: from enzymatic deacetylation to non-enzymatic scaffolding
Type 2 diabetes mellitus (T2DM) is driven by the intricate interplay between metabolic dysregulation and chronic inflammation. However, the comprehensive epigenetic mechanisms linking immune dysfunction to metabolic abnormalities remain incompletely understood. Histone deacetylase 3 (HDAC3), which possesses both deacet...