Lin-Jie Yu

Targeting of NLRP3 Gln624/Ser658 by Carabrone attenuates inflammatory diseases.

The NOD-like receptor family pyrin domain-containing protein 3 (NLRP3) inflammasome plays a crucial role in host defense; however, its aberrant activation leads to excessive release of pro-inflammatory cytokines, triggering inflammatory responses and tissue damage in human diseases. In this study, the inhibitory effect...