Lin-Juan-You Qiao

Multi-lineage reprogramming and NOTCH-associated signaling remodeling characterize the aggressive biology of early-onset colorectal cancer

Introduction Early-onset colorectal cancer (EOCRC), defined as colorectal cancer diagnosed before 50 years of age, represents an emerging global health challenge with rapidly increasing incidence. Although EOCRC exhibits distinct clinical and molecular characteristics, the cellular ecosystem and mechanisms underlying i...