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Author

Linli Li

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Open access Oct 2026

Discovery of a Potent and Selective First-In-Class Antagonist of GPR15 With In Vivo Anti-Obesity Activity.

GPR15 (G Protein-coupled Receptor 15), an atypical chemokine receptor, is implicated in the pathogenesis of multiple diseases, yet small-molecule GPR15 antagonists remain undeveloped. Herein, we identify and characterize YL410, the first-in-class potent and selective GPR15 antagonist. In the cAMP-GloSensor assay, YL410...

Chong Huang, Jing-Xin Qiao, Meng-Qiu Zhou et al. · 0 citations
Jul 2026

Discovery of Deuterated 3,4-Dihydro-benzo[e][1,4]diazepine-2,5-dione Derivatives as Potent, Selective and Orally Bioavailable ROCK2 Inhibitors.

Findings establish 22d as a novel lead compound that impairs breast cancer metastasis through targeted disruption of the ROCK2-STAT3 signaling axis, providing a promising foundation for further therapeutic development against metastatic breast cancer.

Yue-Shan Li, Li-Ting Zhang, Hai-Xing Xu et al. · 0 citations

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