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Review Open access Sep 2026

Dedifferentiated proximal tubular epithelial cells in diabetic kidney disease: pathogenic roles, repair potential, and therapeutic implications

Proximal tubular epithelial cells (PTECs) are more susceptible to damage due to their high energy requirements. The apoptosis of PTECs has been thought as the main cause of diabetic kidney disease (DKD). However, the reported apoptotic rate was around 5%-25%, suggesting that apoptosis alone cannot fully explain disease...

Lei Chen, Fei Wang, Tian-Yi Lv et al. · 0 citations
Open access Sep 2026

Clinical characteristics and genotype–phenotype correlation analysis in 279 patients with 5α-reductase type 2 deficiency

5α-Reductase type 2 deficiency (5α-RD2) is an autosomal recessive differences/disorders of sex development caused by SRD5A2 gene mutations, characterized by impaired testosterone-to-dihydrotestosterone conversion and highly heterogeneous clinical phenotypes. The genotype-phenotype correlation of 5α-RD2 remains...

Kun Wang, Bing-Bing Shi, Li-Li Huang et al. · 0 citations

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