ER+ (estrogen receptor positive) breast cancer is the most common subtype of breast cancer, for which endocrine therapy is the primary treatment. However, the development of drug resistance severely limits the clinical efficacy. In recent years, lipid metabolism reprogramming, as a key metabolic feature of tumor cells...
Zhi-Qi Sui, Xiao-Xi Han, Shao-Chun Liu et al.· Frontiers in Oncology· 0 citations
Background Gut microbiota dysbiosis has been increasingly implicated in autism spectrum disorder (ASD), with the gut-brain axis proposed as a potential mechanistic link. However, ASD-specific microbial signatures remain inconsistent across studies, and whether reported associations reflect primary dysbiosis or ASD-rela...
Le Kang, Lin-Lin Fan, Ying Tian et al.· Frontiers in Microbiology· 0 citations
An integrative stromal-checkpoint framework is used to describe stromal programs that couple extracellular matrix remodeling, metabolic stress, vascular dysfunction, and immune exclusion into treatment-resistant tumor ecologies and discusses how ADAM12-informed biomarkers, spatial barrier profiling, and stromal-priming...
Shao-Chun Liu, Jian Xu, Han Zhang et al.· Cell Communication and Signa...· 1 citation
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