Lin-Lin Lei

Mitochondrial Fis1 tunes Rab7A activity via TBC1D15 modulating STING degradation

SUMMARY The mechanisms governing the final trafficking steps of the cyclic dinucleotide innate immune receptor stimulator of interferon genes (STING) are not fully understood. Here, we identify the mitochondrial protein Fis1 as a regulator of STING endolysosomal degradation. The absence of Fis1 in HeLa cells stabilizes...