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Author

Lin Lu

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Review Open access Sep 2026

Loss of Heterozygosity in Chromosome 11q13 Covering MEN1 and AIP Associates with Aggressive Features in Pituitary Tumors

Around 10% of pituitary tumors are estimated to be aggressive and associated with poor prognosis. Loss of heterozygosity (LOH) in chromosome 11q13 has been observed in aggressive pituitary tumors (APTs). Both MEN1 and AIP, located on 11q13 with an interval of 2.7 Mb, have been discovered as genetic markers of APTs. We...

Shi Chen, Jia-Qi Qiang, Lin Lu et al. · 0 citations
Review Open access Jul 2026

A Novel NR3C1 Frameshift Variant Associated With Familial Glucocorticoid Resistance Syndrome: An Integrated Analysis of Steroid Profiling and Structural Modeling.

A novel exon 2 NR3C1 frameshift variant is described that co-segregates with a characteristic GRS hormonal profile and is supported by clinical, genetic, and structural evidence.

Sufang Yun, Zhifeng Zhu, Fengyee Zhou et al. · 0 citations
Case report Aug 2026

Clinical management challenges of Cushing’s disease associated with double pituitary adenomas: four cases and literature review

DPAs involving a corticotroph component should be considered as a possible explanation for persistent hypercortisolism after TSS when the resected lesion is negative for ACTH and T-PIT and the role of adjunctive molecular imaging remains preliminary.

Di Zhang, Wan Su, Jing-Hua Liu et al. · 0 citations

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