Author

Lin-Quan Bai

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Open access Sep 2026

Deciphering the Genome Evolution and Cryptic Biosynthetic Potential in Rare Lentzea spp.

Background/Objectives: Rare actinomycetes are considered underexplored reservoirs of bioactive natural products, yet genus-level evolutionary processes underlying diversity and novelty in specialized metabolite biosynthetic potential remain poorly understood. Methods: We analyzed 652 high-quality, non-redundant Pseudon...

Ling-Qi Hua, Xing-Zhi Jiao, Wei Huang et al. · Antibiotics · 0 citations

Open access Aug 2026

ETfinder: harnessing conserved C-terminal tails of single-stranded DNA-binding proteins for mining and engineering RecET systems in non-model microbial chassis

ETfinder is presented, a framework that uses the conserved C-terminal tail of host single-stranded DNA-binding proteins (SSB-Ct) as a biochemical constraint to guide the discovery of RecET recombineering systems and prioritizes high-compatibility homologs, reduces experimental screening burden, and expands the accessib...

Dongyuan Lv, Mindong Liang, Yiyang Gu et al. · Nucleic Acids Research · 0 citations

Open access Aug 2026

An efficient endogenous type I-E CRISPR-Cas genome-editing platform for producing transglutaminase in Streptomyces mobaraensis

This study established a robust and efficient endogenous CRISPR-Cas-based genome-editing platform in S. mobaraensis, providing a powerful tool for strain engineering and industrial optimization of TGase production.

Dan Wang, Meng-Jun Sun, Qing-Xu Meng et al. · Engineering Microbiology · 0 citations