Lin-Rong Lu

CTLA-4 haploinsufficiency leads to late-onset autoimmune pathology in mice

Summary In humans, the loss of function in a single copy of the CTLA4 gene leads to an immune disorder characterized by a spectrum of immunodeficient and autoimmune manifestations. To investigate the pathogenicity of CTLA-4 haploinsufficiency, we utilized a heterozygous mouse model carrying a patient-derived Y139C muta...

EBV-reactive KIR+ CX3CR1+ CD8+ T cells mediate liver transplantation tolerance.

BACKGROUND & AIMS Immune tolerance after transplantation reduces immunosuppression-related complications and improves the overall survival rates. The unique tolerogenic microenvironment of the liver enables a proportion of liver transplantation (LT) recipients to develop tolerance with intact liver function. However, t...

GRP75 sustains CD8+ T cell homeostasis and memory generation through ensuring mitochondrial fitness.