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Author

Lin Tao

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Review Sep 2026

Cascades From Caspase‐Dependent Osteoblast Death to Purinergic Signaling in the Pathogenesis of Osteoporosis: Novel Roles of Caspases in Bone Remodeling

Dying cells actively secrete ATP as a ‘find‐me’ signal, which is detected by P2 purinergic receptors on macrophages and activates intracellular purinergic signaling to initiate apoptotic cell clearance. Hyperactivation of purinergic signaling due to excessive extracellular ATP (eATP) is associated with various pathol...

Si-Te Xu, Yun-Han Wang, Wei-Shen Li et al. · 0 citations
Review Open access Aug 2026

Glucose metabolism in osteoporosis: A potential therapeutic target (Review)

It is demonstrated that abnormal glucose metabolism is a key pathogenic mechanism in osteoporosis and that targeting insulin signaling may represent a fundamental strategy for correcting glucose metabolic abnormalities across diverse etiologies.

Sheng-Yao Peng, Z. Yao, Jun-Zhe Guo et al. · 0 citations

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