IL-FormAI: A machine learning-guided framework for screening mRNA-LNP formulations toward improved in vivo expression
The mRNA delivery efficiency of lipid nanoparticles (LNPs) is governed by the chemical structure of ionizable lipid (IL) and formulation. Appropriate formulation optimization may help realize the delivery potential of IL, but current formulation screening methods for newly designed ILs still rely on wet-lab experiments...
Haixing Shi, Jiezhou Chen, Linbo Qing et al.
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