Open access
Oct 2026
The mTOR pathway drives daily physiology
How molecular clocks drive daily rhythms in mammalian physiology remains poorly understood. Here we show that the mechanistic target of rapamycin (mTOR) pathway is required for most daily variation in cellular and organismal physiology. PERIOD2 binds to mTORC1 and limits its activity, providing a route by which the clo...
Aiwei Zeng, A. Mihut, M. Anandapadamanaban et al.
· bioRxiv · 0 citations