Open access
Sep 2026
Endoplasmic reticulum stress reduces caspofungin resistance in Cryptococcus neoformans
ABSTRACT Echinocandin antifungal drugs, such as caspofungin, inhibit β-1,3-glucan synthesis to impair cell wall formation. Caspofungin is effective in the clinic against Aspergillus and Candida species but ineffective against Cryptococcus neoformans, the fungus responsible for life-threatening meningoencephalitis in im...
Xian-Ya Qu, G. Hu, Christopher W. J. Lee et al.
· Msphere · 0 citations