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Author

Linda Engström Ruud

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Open access Sep 2026

Semaglutide engages distinct brainstem-to-hypothalamus circuits to suppress motivated feeding and regulate ketogenesis and energy expenditure

Semaglutide-induced weight loss requires neurons in the dorsal vagal complex (DVC), but how DVC-derived downstream brain circuits coordinate the drug’s effects on feeding and metabolism is unknown. We show that semaglutide suppresses fasting-induced AgRP neuron activation through DVC neurons, including Adcyap1+ neurons...

Sebastian Blid Sköldheden, Júlia Teixidor-Deulofeu, J. Ruud et al. · 0 citations

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