Author

Ling-Feng Wu

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Review Open access Oct 2026

Intramyocellular lipid droplet–mitochondria uncoupling drives muscle atrophy via metabolite-directed epigenetic reprogramming: a review

Type 2 diabetes mellitus (T2DM)-associated sarcopenia is driven by protein degradation and impaired myogenic regeneration. While classical models emphasize cytosolic kinase pathways, the subcellular mechanisms mediating lipotoxicity-induced chronic catabolism remain incompletely understood. This review elucidates a t...

Ling-Feng Wu, Ye Wang, Kai-Lian Ma et al. · Frontiers in Endocrinology · 0 citations

Review Open access Aug 2026

Spatial-Bioenergetic-Immune Axis in Type 2 Diabetes Mellitus-Associated Sarcopenia: A Review from Pathogenesis to Targeted Reconstruction

This review describes T2DM pathogenesis through a novel spatial-bioenergetic-immune axis, stratifying disease progression across three hierarchical levels, and advocates for a transition toward precision clinical management of T2DM-associated sarcopenia, aimed at arresting skeletal muscle degeneration and preserving ph...

Ling-Feng Wu, Hong Ye, Xiao-Feng Wang et al. · Journal of Inflammation Rese... · 0 citations