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Author

Ling Huang

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Sep 2026

Abstract B058: Combining RAS and splicing inhibition in pancreatic cancer

Pancreatic ductal adenocarcinoma (PDAC) is among the deadliest cancer types in the United States, with over 90% of tumors driven by oncogenic KRAS. Several KRAS inhibitors have demonstrated promising preclinical or early clinical efficacy; however, their therapeutic benefit is limited by the emergence of acquired...

Saurabh Mandal, M. Bharmal, Swathi Sridhar et al. · 0 citations
Open access Aug 2026

A pretrained unified model enables cellular functional profile prediction and multi-objective virtual drug screening

Cells are characterized by molecular states, coordinated molecular interactions, regulatory programs, and responses to perturbations. Systematic mapping of these cellular functional profiles across biological contexts remains experimentally costly and fragmented. Here we present InsilicoCell, a pretrained multi-modal,...

Ruoqiao Chen, Li Huang, Yu Qiao et al. · 0 citations

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