Open access
Jul 2026
The roles of Type I interferon subtypes and signaling in mRNA lipid nanoparticle vaccine-induced CD8 T-cell protective immunity 2266569
It is demonstrated that the optimal induction of CD8 T-cells requires IFN-I signaling in multiple myeloid cell types, not just in CD8 T-cells, dendritic cells, or monocytes, and that regulation of IFN-β by NF-κB and all IFN-I subtypes by IRF is required to induce protective CD8 T-cells.
Samit Kafle, Brian Montoya, Carolina R. Melo-Silva et al.
· Journal of Immunology · 0 citations