METTL14‐Mediated N6‐Methyladenosine Exacerbates Acute Lung Injury via USP30/NCOA4‐Dependent Ferroptosis
Findings identify a METTL14/YTHDF1‐USP30‐NCOA4 axis as a potential therapeutic target for ferroptosis‐driven I/R‐induced ALI.
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Findings identify a METTL14/YTHDF1‐USP30‐NCOA4 axis as a potential therapeutic target for ferroptosis‐driven I/R‐induced ALI.
It is demonstrated that the methylation level is highly expressed in the septic liver injury, complying with the up-regulation of m6A methyltransferase METTL4 and the reader YTHDF1, and provides a potential therapeutic target to treat sepsis-induced liver injury.
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