Open access
Sep 2026
Tmem216 deficiency induces hydrocephalus via impaired ciliogenesis and disrupted ependymal planar polarity in mice.
It is demonstrated that central nervous system-specific inactivation of Tmem216 results in severe postnatal hydrocephalus and is identified as a critical TZ protein essential for ciliogenesis during ependymal development and establishing ependymal planar cell polarity.
Qian-Qian Gong, Zhuo-Wen Lv, Zhi-Lin Dou et al.
· Proceedings of the National... · 0 citations