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Author

Ling Xu

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Open access Aug 2026

Heteromeric LGP2-MDA5 receptor complexes drive antiviral signaling

The innate immune receptor MDA5 serves as a first line of defense against RNA viruses by recognizing viral double-stranded RNA (dsRNA) and initiating antiviral signaling. MDA5 is upregulated by another RLR family member known as LGP2, which has been proposed to enhance MDA5 activity by recruiting MDA5 to dsRNA. However...

Gina Buchel, Ling Xu, A. Pyle · 0 citations

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