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Ling-Yu Wu

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Open access Jul 2026

Single-cell and spatial transcriptomics map lung-adaptive metastasis programs through Exoc4, Cd36-vasculogenic mimicry, and Cxcr2 signaling in triple-negative breast cancer.

These results highlight novel prognostic markers and therapeutic vulnerabilities with translational potential for treating TNBC lung metastasis and establish Exoc4, the Hif-2α-Cd36 vasculogenic mimicry axis, Cxcrl1/2-Cxcr2 signaling, and Sftpc as critical mediators of metastatic adaptation.

Hsiao-Chen Lee, C. Kuo, Fang-Ming Chen et al. · Cell Death and Disease · 0 citations