Author

Lingyun Sun

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Review Open access Sep 2026

Mesenchymal stromal cells in age-related neurodegenerative disorders: mechanisms, translational barriers, and precision strategies

Ageing remodels the neuroimmune, metabolic, and vascular environment in ways that accelerate neuronal vulnerability and constrain tissue repair. Mesenchymal stromal cells (MSCs) and MSC-derived extracellular vesicles (MSC-EVs) are therefore attractive candidates for neurodegenerative disorders because their effects ext...

Zhi-Yong Long, Hong-Hao Guo, Ling-Yun Sun · Frontiers in Immunology · 0 citations

Review Open access Aug 2026

Targeting glutathione peroxidase 4 in ferroptosis: from immune regulation to pharmacological development and translational applications

Glutathione peroxidase 4 (GPX4) is a selenocysteine (Sec)-containing antioxidant enzyme and the only known mammalian enzyme capable of directly reducing membrane-embedded phospholipid and cholesterol hydroperoxides. It is recognized as a central regulator of ferroptosis, modulating cellular redox balance and influencin...

Qian-Yue Yang, Yan-Fu Xia, Yong Wu et al. · Frontiers in Pharmacology · 0 citations

Open access Aug 2026

Disease-specific biomarker value of C-reactive protein and its composite indices in autoinflammatory diseases: an integrated study of multi-modal omics and population cohorts

Serum CRP levels showed a disease specific distribution across AIDs, with the highest levels in hyperinflammatory conditions such as AOSD and MAS, suggesting their potential as disease-specific biomarkers.

Qian-Yue Yang, Yu-Lu Zhang, Xiaomin Li et al. · Frontiers in Immunology · 0 citations