An intranasal nanomedicine formulation comprising flap-endonuclease 1 and a panel of hairpin-structured DNA probes designed to concurrently target the highly conserved nucleocapsid RNA and host-derived Cathepsin L mRNA elicited a partial reduction in the viral load in mice infected with SARS-CoV-2, suggesting that this...
Jiyanuo Cao, Meng Wan, Jiayu Gu et al.· Emerging Microbes and Infect...· 0 citations
This review systematically assesses the progress, core strengths, and key translational barriers of four mainstream anti-echinococcosis drug development avenues over the past five years to provide a crucial theoretical foundation and practical reference for precise disease control, optimized clinical strategies, and th...
Lin Wang, Zhengsheng Yan, Si Chen et al.· Current Medicinal Chemistry· 0 citations
It is reported that horseradish peroxidase (HRP) can catalyze artemisinin to generate ROS, and a "ROS bomb" nanomedicine was designed for antitumor immunotherapy, offering a potent approach for treating deep-seated tumors.
Ke-Qiang Lu, Yaoquan Su, Xing-Chen Zhou et al.· Journal of Controlled Releas...· 0 citations
This review systematically summarizes recent advances in nanomedicine enabled GBM therapy from four interrelated perspectives: the optimization of nanomaterial properties, the development of goal-oriented targeting strategies, the rationalization of delivery routes, and the engineering of smart stimuli-responsive nano-...
Yu Guo, Keqiang Lu, Wenmiao Luo et al.· Wiley Interdisciplinary Revi...· 1 citation
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