Open access
Oct 2026
Supramolecular Pretargeting Lipid Nanoparticles Based on Host-Guest Recognition Potentiate Cancer Immunotherapy by Reprogramming Tumor Microenvironment.
CN-LNPs are employed as a delivery platform to encapsulate a circular RNA encoding IL-2-Fc fusion protein, enabling intratumoral cytokine production to potentiate antitumor immunity and establish a versatile platform that overcomes the intratumoral delivery limitations commonly associated with conventional LNPs system.
Jin-Qun Gan, Yang-Fan Wang, Meng-Yao Li et al.
· Angewandte Chemie · 0 citations