Open access
Jul 2026
Metabolic reprogramming via SIRT2-deficient microglial large extracellular vesicles ameliorates alzheimer's pathology.
LEVs are identified as a critical vesicle subtype mediating the effects of SIRT2 knockdown and support a cell-free therapeutic strategy for AD centered on EVs-driven metabolic reprogramming of microglia.
Xiaolu Tang, Rui Chen, Jiawei Xing et al.
· Journal of Neuroinflammation · 0 citations