Author

Lipin Loo

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Open access Oct 2026

DHODH is the key target of the KDM4 inhibitor QC6352 in glioblastoma stem cells.

Histone lysine demethylase 4 (KDM4) enzymes are frequently overexpressed in cancer and are considered to be promising therapeutic targets. QC6352, which is widely used as a best-in-class KDM4 chemical probe, shows potent antitumor activity across cancer models. Using comprehensive chemical biology approaches in gliobla...

Jayden Sterling, Jacinda R. Holtsmark, George L. Joun et al. · Nature Chemical Biology · 1 citation

Open access Sep 2026

Proteolytic control of the SARS-CoV-2 furin cleavage site defines the phenotypic evolution from the pandemic to endemic state

The successive emergence of SARS-CoV-2 variants with altered tissue tropism has progressively decoupled transmissibility from lower respiratory tract pathogenicity. Omicron lineages transmit exceptionally well whilst limiting severe lung disease. Here, we demonstrate that this phenotype has evolved through two temporal...

A. Aggarwal, S. Ognenovska, Timothy Ison et al. · bioRxiv · 0 citations