Lis de Paula Lacerda

Cascade genetic testing and early detection in families with hereditary breast and ovarian cancer within the brazilian public health system

Introduction: Approximately 5–10% of breast and ovarian cancers are hereditary, predominantly associated with pathogenic variants in BRCA1, BRCA2, and TP53. Cascade genetic testing in at-risk relatives is a cost-effective strategy to enable early detection, targeted prevention, and precision oncology. In the Brazilian...