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Author

Lisa Husband

2 papers indexed here

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Open access Sep 2026

Pulmonary Penetration of Intravenous Rifabutin in Healthy Participants: A Multiple-Dose Pharmacokinetic Study.

BACKGROUND Carbapenem-resistant Acinetobacter baumannii causes severe respiratory infections with limited therapeutic options and high mortality. Although rifabutin exhibits potent activity against A. baumannii, oral administration results in low bioavailability and variable exposure. An intravenous formulation (BV100)...

V. al Jalali, Anselm Jorda, Lena Pracher et al. · 0 citations
Clinical trial Open access Sep 2026

BV100 (rifabutin IV) drug interaction studies in healthy subjects with index CYP450 3A probes midazolam and itraconazole

BV100 is a mild/weak CYP3A enzyme inducer and a mild substrate for CYP3A inhibitors, however, co-administration with strong CYP3A inhibitors resulted in a disproportionate increase in exposure to the active metabolite 25-O-desacetyl rifabutin, leading to an ∼2-fold increase in total active-moiety exposure.

Pierre Delique, C. Kemmer, Lisa Husband et al. · 0 citations

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