Lisa Lucke

Proteasome inhibition alleviates proteinuria in Lmx1b knock-in mice with dysfunctional LIM domains

Mutations in the transcription factor LMX1B have been identified as the cause of the autosomal-dominant disease nail-patella syndrome. It manifests in small or absent patellae and dysplastic or missing toe- and fingernails, but the prognosis of the patients is determined by the development of renal symptoms due to dysf...