Author

Lisa M. Coussens

2 papers indexed here

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Open access Aug 2026

Plectin promotes an aggressive phenotype and represses cytotoxic T cell activity in pancreatic cancer

Background Pancreatic adenocarcinoma (PDAC) is an abysmal disease with poor clinical outcomes, largely due to limited life-extending treatments. Notably, PDAC displays a T cell-suppressive tumor microenvironment, and the underlying molecular mechanisms that lead to this phenotype remain poorly understood. Methods Utili...

Cody L. Wolf, Roxanne K. Ruiz, Sokchea Khou et al. · Frontiers in Immunology · 0 citations

Sep 2026

The post-transcriptional regulator HuR promotes immune evasion in pancreatic ductal adenocarcinoma.

The tumor microenvironment (TME) of pancreatic ductal adenocarcinoma (PDAC) is characterized by restrained function of effector T cells that drives resistance to immunotherapy. While tumor-extrinsic stroma and myeloid cells have been shown to mediate PDAC immune evasion, the role of tumor-intrinsic post-transcriptional...

Yi-Fei Guo, Jennifer M. Finan, Alexandra Q. Bartlett et al. · Cancer immunology research · 0 citations