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Lisanne Pitzke

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Open access Sep 2026

Msp1-dependent extraction promotes ubiquitylation of translocation-stalled mitochondrial precursor proteins

The translocase of the outer membrane (TOM complex) imports more than 1,000 proteins into mitochondria. Clogging of the TOM pore with a precursor protein causes proteotoxic stress and eventually cell death. Two quality control pathways remove translocation-stalled precursor proteins. In the mitochondrial protein transl...

Jeannine Engelke, Noemi Occhipinti, Lisanne Pitzke et al. · 0 citations

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