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Sponsored Artificial Intelligence: A Modern Approach, Global Edition Artificial Intelligence: A Modern Approach, Global Edition

Author

Litao Sun

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4 papers indexed here

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Open access Sep 2026

Structural Conservation and Assembly Plasticity of a Divergent Phenuivirus Nucleoprotein

Tick-borne phenuiviruses include a diverse set of emerging pathogens whose nucleoproteins (NPs) package viral RNA despite extensive sequence divergence across lineages. We examined the NP of Tacheng tick virus 2 (TcTV2), a highly divergent member of the genus Uukuvirus. Phylogenetic analysis of an expanded NP dataset s...

Shan Du, Li-Xuan Qi, Wen-Ni Zhang et al. · 0 citations
Open access Oct 2026

Inhibition of the NR4A1-mediated cell cycle checkpoint enhances hyperplastic adipogenesis and glucose homeostasis in obesity.

BACKGROUND AND PURPOSE The nuclear receptor NR4A1 is a critical node in transcriptional circuits for metabolic adaptation, yet its role in adipocyte progenitor (AP) fate and proliferation is unclear. We sought to define how NR4A1 governs early adipogenesis and adipose tissue plasticity. EXPERIMENTAL APPROACH Doxycycl...

Wan-Ning Qiao, Cun Ku, G. V. Naveen Kumar et al. · 0 citations
Open access Aug 2026

Pharmacologic eIF2B Activation Rescues Neuropathy in CMT2 Subtypes by Normalizing the Integrated Stress Response

This study identifies candidate biomarkers for CMT disease subtypes associated with defects in translational homeostasis and supports eIF2ɑ-ATF4 axis modulation as a promising therapeutic strategy for this disease class.

Mary McMahon, Steve Lianoglou, Sridhar Narayan et al. · 0 citations
Open access Jul 2026

Structural insights into the nairovirus nucleoprotein endonuclease activity.

Results reveal an expanded functional repertoire of nairovirus NPs and suggest that NP-mediated RNA discrimination may contribute to viral replication, and support the feasibility of targeting NP for the development of antiviral drugs against emerging nairoviruses.

Zan Li, Shan Du, Feng Gao et al. · 0 citations

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