Author

Liudmila Kulakova

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Open access Aug 2026

Incorporation of native HCV E1E2 into a nanoparticle vaccine platform

These studies show that a well-characterized sE1E2 platform compatible with multiple genotypes can be coupled to nanoparticles for use as a vaccine candidate and sets the stage for further exploration of nanoparticles and other multivalent platforms for the development of E1E2-based vaccines.

Liudmila Kulakova, Sarah Jeong, Dong-Xiu Zhang et al. · bioRxiv · 0 citations

Open access Jul 2026

Induction of Robust Immunity Against Hepatitis C Virus Using Rationally Adjuvanted Microneedle Patches Integrating A Secreted Form of E1E2 Heterodimer 2259568

The preclinical development of a novel HCV vaccine candidate engineered by formulating a novel native-like secreted E1E2 immunogen and a well-established combinatorial adjuvant of QS-21 + 3D-(6-acyl) PHAD into unique microneedle patches (MNPs).

Yi-Nuo Zhang, A. Dhayani, Stephen C. Balmert et al. · Journal of Immunology · 0 citations