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Lixin Zhang

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Open access Aug 2026

TROP2-targeting chimeras (TRTACs) for tumor-selective membrane protein degradation and enhanced drug delivery

These findings establish TROP2 as a robust LTR and provide a versatile eTPD platform with profound translational potential for tumor treatment, as well as design TRTAC-drug conjugates, enabling targeted protein degradation together with enhanced drug delivery.

Luping Chen, Xinying Fu, Wenqian Dong et al. · 0 citations
Aug 2026

TRACER navigates rearrangement-driven sesterterpene chemical space via multimodal enzyme-product representation learning

TRACER (terpene rearrangement annotation via co-attentive enzyme-product representation), a multimodal framework mapping the latent associations between sequence-derived enzyme representations and product chemotypes, establishes a predictive paradigm for the rational discovery and mechanistic elucidation of complex terpene architectures.

Cuiping Xing, Kangjie Lv, Weiyan Zhang et al. · 0 citations