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Author

Liyan Yang

2 papers indexed here

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Open access Sep 2026

Stepwise reorganization of chromosome conformation and nuclear organization during stem cell differentiation

Nuclear organization is a fundamental feature of cell identity and cell fate determination. Compared with differentiated cells, pluripotent stem cells exhibit markedly distinct nuclear architecture at multiple levels, including chromosome folding, lamina association, histone modification landscapes and nuclear body org...

Xiangru Huo, D. Lafontaine, Thomas Reimonn et al. · 0 citations
Open access Aug 2026

Formation of an RNA-mediated nuclear compartment

Mammalian nuclei are spatially compartmentalized so that active and inactive segments of the genome occupy separate sub-nuclear neighborhoods. Compartments are often found in association with nuclear structures such as the nuclear lamina, nucleoli, and nuclear speckles (speckles), suggesting links between them. The mol...

D. Lafontaine, Ezequiel Calvo-Roitberg, Yu-Chieh Chung et al. · 0 citations

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