Loïc C. Caloren

Prefibrotic bone marrow microenvironment is a hallmark of clonal hematopoiesis.

Clonal hematopoiesis of indeterminate potential is associated with systemic inflammation and increased malignant risk in humans, yet understanding of how it reshapes the bone marrow (BM) microenvironment has been limited. Using single-cell transcriptomic profiling of freshly isolated BM samples, combined with histologi...