Author

Loïc Rolas

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Open access Sep 2026

Orphan GPR84 facilitates uropod de-adhesion at multiple steps during leukocyte extravasation.

Leukocyte migration through venular walls is an essential component of effective immunity. While the key molecular players driving the initial steps of this response are known, the terminating signals remain unclear. Here, we identify a conserved role for GPR84 family GPCRs in the successful completion of the final sta...

Clare Latta, Terrence M. Trinca, Francesca Robertson et al. · EMBO Reports · 0 citations

Open access Aug 2026

Endothelial PIEZO1 regulates Weibel-Palade body exocytosis.

It is demonstrated that the opening of a mechanosensitive cation channel PIEZO1 on the EC surface triggers rapid WPB exocytosis and a mechanosensitive molecular pathway coupling inflammation with haemostasis is revealed.

Sammy El-Mansi, M. Al-Saegh, Loïc Rolas et al. · Blood · 0 citations