Author

Lona M. Alkhalaf

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Open access Sep 2026

Structural and biochemical characterisation of an iterative GCN5-related N-acetyltransferase required for fungal siderophore tailoring

Siderophore-mediated iron acquisition is essential for fungal survival, particularly under iron-limiting conditions. In Aspergillus fumigatus, SidG, a member of the GCN5-related N-acetyltransferase (GNAT) superfamily, catalyses the final step in the biosynthesis of the extracellular siderophore triacetylfusarinine C (T...

Joseph D. Newman, Y. T. Candace Ho, Christopher D. Fage et al. · bioRxiv · 0 citations

Open access Aug 2026

Carbene Footprinting and Mass Spectrometry Capture Global Conformational Changes in Elongation Factor-Tu Induced by Antibiotic Binding

Carbene footprinting methodology, in combination with mass spectrometry, was employed to study the interactions of bacterial elongation factor-thermo-unstable (EF-Tu) with two antibiotics. EF-Tu, a GTPase, delivers aa-tRNA to the ribosome during protein synthesis where it undergoes a significant conformational switch...

Cameron Baines, Daniel C L Van, Lona M. Alkhalaf et al. · ACS Chemical Biology · 0 citations