Long-Yang Zhao

Novel quinoline-2-one derivatives as potent receptor Interacting protein kinase 1 (RIPK1) inhibitors with therapeutic activities for acute respiratory distress syndrome

As a key regulator of cellular programmed necrosis and inflammatory signaling pathways, receptor interacting protein kinase 1 (RIPK1) is closely linked to the pathogenesis and progression of acute respiratory distress syndrome (ARDS). In this study, building on hits identified from docking simulations, a series of qu...