Open access
Oct 2026
TRIM65-BTG3-HIF-1α axis drives osteosarcoma progression via M2 macrophage polarization and angiogenesis
Abstract Background and Objectives Osteosarcoma (OS) is an aggressive bone cancer with a poor prognosis, especially in metastatic cases. The tumor microenvironment (TME), particularly tumor-associated macrophages (TAMs), plays a crucial role in its progression. This study aimed to investigate the role and mechanism of...
Hao Wang, Rui Yang, Zhong-Xuan Wu et al.
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