Lorenz M. W. Holzner

Propionic acidemia as a framework for understanding the impact of disturbed propionyl-CoA on histone modifications

Abstract Histone propionylation—the transfer of a three-carbon propionyl group from propionyl-CoA to lysine residues—is an emerging post-translational modification (PTM) with potential effects on gene expression. Interest in this PTM has grown because propionyl-CoA is at the interface between valine, isoleucine, methio...