Review
Oct 2026
A context-dependent framework for targeting NAD metabolism in cancer.
Nicotinamide adenine dinucleotide (NAD) occupies a privileged position at the intersection of cellular bioenergetics, redox homeostasis, and signal transduction. Beyond its canonical role in ATP synthesis, NAD serves as an obligate cofactor for enzymes including poly(ADP-ribose) polymerases (PARPs), sirtuins, and CD38,...
Leire Arrizabalaga, Laura Santambrogio, G. Kroemer et al.
· Cell Metabolism · 0 citations