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Lorenzo Gorga

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Open access Sep 2026

Effect of Linker Sequence on the Interdomain Dynamics of Self-Sufficient CYP116B5-SOX Chimeras

In this work, the design of CYP116B5-SOX(PPII) is presented. This is an artificial self-sufficient enzyme in which the P450 116B5 peroxygenase and the H2O2-generating sarcosine oxidase (SOX) are linked together in a fusion complex. A polyproline type II helix (PPII) linker was used to connect the two enzymes, obtaining...

Daniele Giuriato, Lorenzo Gorga, S. Castrignanò et al. · 0 citations

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