Author

Loretta Ferrera

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Open access Aug 2026

Mechanistic Insights into CFTR Potentiation by the Antimicrobial Peptide Esc(1–21): Direct Interaction with the NBD1-NBD2 Interface

The first mechanistic insights into the interaction of Esc(1–21) with CFTR in a cellular context are provided and the NBD1-NBD2 interface is identified as a suitable target for peptide-based potentiators to support the development of Esc(1–21) and its derivatives as novel multifunctional therapeutic candidates for CF treatment.

D. Baroni, Loretta Ferrera, Mario Passalacqua et al. · ACS Omega · 0 citations