The dual incretin agonist tirzepatide blunts nicotine-induced behaviours and neurochemistry in male mice.
BACKGROUND AND PURPOSE Nicotine dependence remains one of the leading causes of morbidity and mortality worldwide, with high relapse rates and post-cessation weight gain representing persistent barriers to sustained abstinence. The incretin hormones glucose-dependent insulinotropic polypeptide (GIP) and glucagon-like p...