Its favorable binding characteristics, electronic stability, and predicted brain permeability highlight apigenin as a potential candidate for the prevention and treatment of neurodegenerative diseases, warranting further experimental and clinical validation.
Computer docking reports have revealed positive results between arbutin, acetoside, and key targets of PD, and phenolic glycosides are highlighted as promising multitarget neuroprotective candidates for PD.
Anish Singh, Diksha Dalal, Lovedeep Singh· Indian Journal of Pharmacolo...· 0 citations
Fisetin represents a promising multi-target therapeutic candidate for the management of inflammation-associated neurodegenerative disorders and simultaneously targets interconnected inflammatory, oxidative, apoptotic, and proteostatic pathways implicated in neurodegeneration.
Given the multifaceted interaction of various mediators in the pathophysiology of PD, and the potential of baicalein to regulate these processes, the current review has been structured to examine the mechanisms by which baicalein can produce its antiparkinsonian effects.
Combined in silico and experimental findings highlight hesperidin’s strong binding to key molecular targets, whereas experimental evidence also confirms its antioxidant, anti-inflammatory, and anti-apoptotic effects, supporting its potential as a disease-modifying candidate in PD therapy.
Seyawash Ghani, Diksha Dalal, Anish Singh et al.· Current Behavioral Neuroscie...· 0 citations
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