Author

Lu-Jia Liu

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Open access Aug 2026

Quercetin protects HTR-8/SVneo human trophoblast cells against oxidative stress injury via activating EGFR/PI3K/AKT-NRF2/HO-1 signaling axis

Investigating whether quercetin alleviates H2O2-induced oxidative damage in HTR-8/SVneo trophoblasts via regulating the EGFR/PI3K/AKT-NRF2/HO-1 axis provided a novel mechanism and potential intervention for adverse pregnancy outcomes.

Lu-Jia Liu, Zhixian Ding, Yi-Na Wu et al. · Frontiers in Pharmacology · 0 citations

Review Open access Aug 2026

Iron regulation by Sirtuins 1 & 2 and their therapeutic modulation by Sirtinol

This review focuses on the role of SIRTs 1 & 2 as tumor promoters, providing a rationale for developing inhibitors like sirtinol for these enzymes, and examines sirtinol’s anti-tumor properties in relation to its ability to function as a tridentate iron chelator.

Koffi Amegble, Lu-Jia Liu, To-Ni Q. Duan et al. · Frontiers in Pharmacology · 0 citations