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Oct 2026

PPARγ/P21 Signaling Mediates Butyrate-Driven Protection against Aging-Related Endothelial Dysfunction: A Novel Effect of Soybean Polysaccharide via the Gut-Vascular Axis

Aging-induced endothelial dysfunction is a core driver of age-related cardiovascular diseases (CVDs). In 20-month-old naturally aged mice, 12-week soybean polysaccharide (SP) supplementation restored endothelium-dependent relaxation, reduced aortic reactive oxygen species and VCAM-1 in the aortic endothelium, and att...

Qi-Le Zhang, Zheng-Ming Zhou, Hoi-Wa Yeung et al. · 0 citations
Open access Oct 2026

Microbiota-host genetic interactions modulate MASLD risk in PNPLA3I148M carriers via ceramides and are reversible by targeted microbial interventions.

BACKGROUND The factors that determine when genetic susceptibility to metabolic dysfunction-associated steatotic liver disease (MASLD) progresses to clinically significant liver injury remain incompletely understood. OBJECTIVE We investigated whether disruption of the intestinal host-microbiota interface acts as a con...

Madhuri Haque, T. Lesker, U. Rolle-Kampczyk et al. · 0 citations

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