Piezo channels are integral to numerous physiological functions: Piezo 1 modulates blood pressure through shear stress sensing and plays a role in cellular development and epigenetic processes. Conversely, Piezo 2 is implicated in sensory perceptions, including tactile sensation, balance, and nociception. Piezo channel...
Exosomes offer a promising vehicle for noninvasive diagnosis of neurodegenerative diseases by carrying multiple biomarkers across the blood-brain barrier. However, traditional exosome analysis often misses subtle genotype-specific variations because of weak signals from a few exosomes, reliance on markers, and limited...
Jinhee Yoo, Youngjun Kim, Won Jong Yu et al.· Science Advances· 0 citations
Stem-cell-derived extracellular vesicles (EVs) that carry bioactive proteins and nucleic acids reflecting the parental cells offer a promising route for cell-free cardiac regenerative medicine. However, the origin, composition, and function of EVs derived from differentiating human induced pluripotent stem cells (iPS...
Xiao-Dan Dai, Liang Hu, Lu-Ke P. Lee et al.· ACS Nano· 0 citations
Lung cancer therapy is severely hindered by the pulmonary mucus barrier and chemotherapy resistance driven by therapy-induced senescence (TIS) following DNA-damaging agents. Herein, we report an inhalable, mucus-penetrating nanoliposomes (DR@DPPC-Apt) engineered by incorporating an L1 cell adhesion molecule (L1CAM)-tar...
Yun-Qi Man, Yan-Fei Liu, Yong-Bo Liu et al.· Biomaterials· 0 citations
This review provides a conceptual framework for navigating the critical design trade-offs inherent in engineering DNA nanostructures for in vivo application and offers forward-looking perspectives for the development of DNA-based nanocarriers.
Jun-Gang Ren, Qian Wu, Lu-Ke P. Lee et al.· ACS Applied Materials and In...· 0 citations
This review systematically maps the molecular architecture of the senescent-cell heterogeneity, off-target toxicity, and the lack of standardized biomarkers, and provides a framework for developing precision strategies to detect, modulate, or eliminate senescent cells in a context-appropriate manner.
Ze-Xiang Lv, Yan-Fei Liu, Yong-Bo Liu et al.· ACS Biomaterials Science & E...· 0 citations
This human iPSC-derived tumor–brain organoid platform provides a reliable and scalable system for studying complex tumor-neural interactions and exploring therapeutic approaches that aim to eliminate the tumor while preserving neural function.
Ewa Grassin, H. Chintalapudi, Xianjun Dong et al.· bioRxiv· 0 citations
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